Gene machines, one molecule at a time

Gene expression is the vital path that converts DNA information into functional proteins. Our group studies mechanisms and machines of gene expression using single-molecule biophysical methods and biochemistry. We observe single biomachines in real time, both "in vitro" and in living cells. We also develop single-molecule fluorescence methods, assays and DNA-based biosensors.

Our team is a Biological Physics research group within Condensed Matter Physics. We are also linked to the Doctoral Training Centre (DTC) and the Wellcome Trust graduate programme in structural biology.

News accordion

Expand All

We have an exciting new studentship available in the lab – we are looking for someone with an interest in using cutting edge microscopy to answer fundamental questions about the morphology and cellular interactions of RNA viruses. This is a 4 year, Royal Society-funded DPhil in Biophysics. For more info please see: Link.
- It has been a busy month for papers, check out our exciting new work on the E.coli RNA polymerase, published in Mol. Cell Link and Nature Communications Link.
- We also have two new papers uploaded on BioRxiv! Link and Link.
- Congratulations to Maabur for winning the Arthur H Cooke Memorial Prize, which is awarded for distinguished work by a first year research student in Condensed Matter Physics. Well done!!!
- We say goodbye to our two MPhys students Amy Kent and Joseph Dolphin and wish them the best of luck with their exams!
- Team Rapinidis is running the Oxford Town and Gown 10K, in aid of Muscular Dystrophy UK, on the 13th of May. Our team has grown since last year and we are all training hard. If you would like to donate to this great cause please see our Justgiving page below: Link.

For student and postdoctoral enquiries (with CV), e-mail
Professor Achilles Kapanidis.

Funding Sources:



Seventh Framework Programme




wellcome trust